Has Nattokinase have any side effects?

Nattokinase has been used as a supplement for nearly 20 years with no known side effects. In fact, Nattokinase has demonstrated most of the benefits of pharmaceutical agents designed to restrict blood clotting (such as Warafin, Herapin and t-PA) without any of the side effects of those medications. In addition, it has not been recognized to cause any allergic reactions, there have never been any reports of toxicity associated with Nattokinase supplementation.

Nattokinase 1500 by Naturally Vitamins

Nattokinase is an enzyme extracted from natto cheese, a dietary staple in Japan and believed to be the reason behind the country’s record low rate of heart disease.

For those seeking for a pure, potent source of nattokinase without having to travel to Asia, look no further! Nattokinase 1500 from Wobenzym USA provides a whopping 1500 fibrin units (FU) of nattokinase per serving.

Unlike other similar products, Nattokinase 1500 is an enterically coated tablet. Each tablet passes through the stomach without being digested, where they are then absorbed into the blood stream via the small intestine. It is here in the blood stream where nattokinase gets to work. Other products, which get digested in the stomach, become less effective once they finally reach the bloodstream.

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The Benefits of Nattokinase on Blood Pressure

Traditionaly in Japan, Natto has been consumed not only for cardiovascular support, but also to lower blood pressure. In recent years, this traditional belief has been confirmed by several clinical trials. In 1995, researchers from Miyazaki Medical College and Kurashiki University of Science and Arts in Japan studied the effects of nattokinase on blood pressure in both animal and human subjects (see below). In addition, the researchers confirmed the presence of inhibitors of angiotensin converting enzyme (ACE), which converts angiotensin I to its active form angiotensin II within the test extract, which consisted of 80% ethanol extract of lyophilized viscous materials of natto. ACE causes blood vessels to narrow and blood pressure to rise - by inhibiting ACE, nattokinase has a lowering effect on blood pressure.1,2

Animal Study

After a single intraperitoneal administration of 400-450 grams of the test extract (equivalent to 25 mg of natto food) into male Wister rats, systolic blood pressure (SBP) significantly decreased from 166 + mmHg to 145 + 24 mmHg in just two hours (p<0.05),>

Human Study

The same natto extract was then tested on human volunteers with high blood pressure. Blood pressure levels were measured after 30 grams of lyophilized extract (equivalent to 200 grams of natto food) was administered orally for 4 consecutive days. In 4 out of 5 volunteers, the systolic blood pressure (SBP) decreased on average from 173.8 + 20.5 mmHg to 154.8 + 12.6 mmHg. Diastolic blood pressure (DBP) decreased on average from 101.0 + 11.4 mmHg to 91.2 + 6.6 mmHg. On average, this data represents a 10.9 percent drop in SBP and a 9.7 percent drop in DBP.1,2,6

Source:www.betterhealthinternational.com/lib_Nattokinase.asp

Reviews by Customers on Nattokinase

As Nattokinase is widely use by some many people as it get so many health benefits as is proved by research and studies, here some customers reviews on Nattokinase which is given at Allnutri are given below:

Alan Sandor - HI, USA
I and my spouse both take nattokinase as a supplement for normal blood pressure, because both of us suffer from high blood pressure, our doctor recommended it. Apart of under normal blood pressure nattokinase also help me to controlling the pain on my legs. This is the extra benefit which I not intentionally taking it for. Thanks to nattokinase for solving our problems.

Marshall Gomes - KY, USA

I have been taking Nattokinase for more than a year. My doctor gives me advice to take them & he said that I had poor circulation in my hand and it was causing me a lot of pain. After using Nattokinase one capsule daily I felt less pain within two weeks so I decided to continue to use Nattokinase. Now one year ago and now I didn't feel any pain on my hand. Thank Nattokinase.

MURDIE - ID, USA

I am taking this product for almost 3 months, It has been effective in controlling pain in the legs as doctor indicated. From the very first day when I started Nattokinase i feel better and after two week I felt much better from first day and i decided to continue Nattokinase product. Thank you for making this fine natural product.

Nattokinase Complex by Solgar

Nattokinase is a patented beneficial soy enzyme isolated by scientists from heart-healthy soybeans. Solgar's Nattokinase Complex Softgels offer nattokinase that has gone through rigorous testing to confirm 1,000 units of fibrinolytic activity per softgel. The testing methods used correspond with the only approved methods of the Japan Nattokinase Research Association. Solgar's Nattokinase Complex Softgels also include coenzyme Q-10 for cardiovascular support, high-potency vitamins C and E which supply favorable antioxidant properties and Pycnogenol®, a unique and powerful plant extract that offers naturally-occuring flavonoids.

Nattokinase Research Update

Dietary supplementation with fermented soybeans suppresses intimal thickening.
Nutrition. 2003 Mar;19(3):261-4.
Although soy foods have been consumed for more than 1000 years, it is only in the past 20 y that they have made inroads into Western diets. We investigated the effect of dietary supplementation with natto extracts produced from fermented soybeans on intimal thickening of arteries after vessel endothelial denudation. Natto extracts include nattokinase, a potent fibrinolytic enzyme having four times greater fibrinolytic activity than plasmin. Intimal thickening was induced in the femoral arteries by intravenous infusion of rose bengal followed by focal irradiation with a transluminal green light. Nattokinase extract supplementation was started 3 wk before endothelial injury and continued for another 3 wk after. Nattokinase supplementation suppressed intimal thickening compared with the control group. Nattokinase shortened euglobulin clot lysis time, suggesting that their thrombolytic activities were enhanced. These findings suggest that nattokinase, because of its thrombolytic activity, suppress intimal thickening after vascular injury as a result of the inhibition of mural thrombi formation.

Nattokinase by NutriCology

2000 FU Isolated and purified nattokinase, an enzyme derived from a process of fermentation involving boiled soybeans and Bacillus natto. Research has shown nattokinase to support the body in breaking up and dissolving the unhealthy coagulation of blood and to support fibrinolytic activity.Vitamin K2 has been removed.