Nattokinase Complex by Solgar

Nattokinase is a patented beneficial soy enzyme isolated by scientists from heart-healthy soybeans. Solgar's Nattokinase Complex Softgels offer nattokinase that has gone through rigorous testing to confirm 1,000 units of fibrinolytic activity per softgel. The testing methods used correspond with the only approved methods of the Japan Nattokinase Research Association. Solgar's Nattokinase Complex Softgels also include coenzyme Q-10 for cardiovascular support, high-potency vitamins C and E which supply favorable antioxidant properties and Pycnogenol®, a unique and powerful plant extract that offers naturally-occuring flavonoids.

Nattokinase Research Update

Dietary supplementation with fermented soybeans suppresses intimal thickening.
Nutrition. 2003 Mar;19(3):261-4.
Although soy foods have been consumed for more than 1000 years, it is only in the past 20 y that they have made inroads into Western diets. We investigated the effect of dietary supplementation with natto extracts produced from fermented soybeans on intimal thickening of arteries after vessel endothelial denudation. Natto extracts include nattokinase, a potent fibrinolytic enzyme having four times greater fibrinolytic activity than plasmin. Intimal thickening was induced in the femoral arteries by intravenous infusion of rose bengal followed by focal irradiation with a transluminal green light. Nattokinase extract supplementation was started 3 wk before endothelial injury and continued for another 3 wk after. Nattokinase supplementation suppressed intimal thickening compared with the control group. Nattokinase shortened euglobulin clot lysis time, suggesting that their thrombolytic activities were enhanced. These findings suggest that nattokinase, because of its thrombolytic activity, suppress intimal thickening after vascular injury as a result of the inhibition of mural thrombi formation.